REBEL Cast Ep116: The CLOVERS Trial – Restrictive vs Liberal Fluids in Sepsis-Induced Hypotension
REBEL Cast
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Introduction
Rebelcast Episode 116: Restrictive vs. Liberal Fluids in Sepsis-induced Hypotension. Swami and Salim discuss the Clover's Trial, a randomized double-blind placebo-controlled trial looking at whether we should be using early vasoactive substances like norepinephrine to treat septic shock. They also look at how data drives them to maybe think about this differently.
Transcript
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Background: IV fluids are part of the standard resuscitation bundle in septic shock, however it is unclear if they provide a significant benefit. These patients can have a vasodilated vascular bed and the initial use of fluids is hypothesized to serve two purposes: Augmenting the macrovascular system (stroke volume and cardiac output) and augmenting the ... 
