#104 Guideline-Directed Medical Therapy for HFrEF Part 1: 5 Pearls Segment
Core IM | Internal Medicine Podcast
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The Paradime Trial
Arne's decrease cardo vascular death and heartfailer hostilization even more than an alapro. There are two parts of the way the paradime trial was designed that are controversial when we look back at it. The other issue is they had a really long run in period that patients needed to be able to tolerate for several weeks before they were able to be in the trial. And so by virtue of selecting for a group of patients who already tolerate the drug, you're going to overestimate the treatment effect in the real world. Ra, why i have a feeling tat gragg may point out some questionable sutty design here.
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