Question: Can MTHFR cause ADHD?So, methylation will reduce the background level of tonic dopamine. And make you more mentally flexible. And a lack of methylation will generally lead to a higher level of background dopamine and make you not as mentally flexible. So, I really don't think that the ADHD is solely a consequence of MTHFR. Low methylation state and glycine wasting is probably playing into some of the aggravating factors, particularly glycine wasting.

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