The Differences Between Familial Hypercholesterolemia and Lean Mass Hyper Responders

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This chapter explores the immunologic differences between individuals with familial hypercholesterolemia (FH) and lean mass hyper responders, highlighting why FH is not a good model system. It also discusses the relationship between lipid metabolism and the immune response, particularly in the context of macrophages and atherosclerosis. The chapter showcases a study that examines physically different macrophages in individuals with monogenetic FH and discusses the potential benefits of lipid-lowering therapy for those with FH.

Today, Paul has Dave Feldman on the podcast to discuss, in depth, a recent study that he conducted about LDL and cardiovascular risk and what this may mean for the future of medicine.

*Produced by Mountain Valley Media

00:03:30 The genesis of Dave’s most recent study

00:07:00 is FH a phenotype or genotype polygenetic vs monogenetic

00:22:30 Dave’s overall perspective while conducting studies

0:24:00 Diving into Dave Feldman’s most recent study: Does APOE-B cause atherosclerosis

00:42:30 How the medical community has received this study

00:46:30 Do credentials matter?

00:58:30 Thoughts on Statins

01:04:45 What alters lipid levels

01:13:30 Connect with Dave

References:

Twitter: @realdavefeldman