Preventing cancer. Curing depression. Single-handedly ending the COVID-19 pandemic. Oh, and something to do with your bones. Is there anything Vitamin D can’t do?
Maybe the answer is: “quite a lot”. In this episode of The Studies Show, Tom and Stuart look into the claims about the wondrous powers of Vitamin D supplements - and whether any of them have any decent evidence behind them. The whole story turns out to be a perfect parable for how to think about health research.
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Show notes
* Rupa Huq MP’s article from during the COVID pandemic on how the government should be “shouting about Vitamin D”
* Huq and David Davis MP convince the government to recommend Vitamin D
* Stuart’s New Statesman article on why this was jumping the gun a little
* How Vitamin D regulates calcium and phosphorus metabolism in the body
* Might it slow tumour growth? Or prevent cardiovascular disease? Evidence from rats
* Observational studies on how Vitamin D levels are related to: depression, cognitive impairment, cancer rates, cardiovascular disease, all-cause mortality
* Review paper claiming widespread deficiency in Vitamin D
* Scientific American article including discussion of the confusion over what it means to be “deficient” in, and/or have an “insufficiency” of Vitamin D
* 2019 paper reporting results from the VITAL trial on cancer and cardiovascular risk
* D-health trial results on cancer risk and cardiovascular risk
* From the D-health trial, papers reporting no effect of Vitamin D supplementation on: cognitive impairment, depression, microbiome diversity, telomere length, hypothyroidism, erectile dysfunction, falls, fractures
* Classic xkcd cartoon on false-positive jelly beans
* 2022 Nature Reviews Endrocrinology review on the (lack of) evidence for the effects of Vitamin D beyond bone-related problems
* Story of UK man who died of a Vitamin D overdose
* Vitamin D and COVID: the promising observational study; the null trial
Credits
The Studies Show is produced by Julian Mayers at Yada Yada Productions.
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