Is It a Single Mino Acid Change That Causes the Expansion of the Active Sit Now?

The first structural change was s h v, was two. It's those singlar minoesti changes that cause the expansion of the active sit. The opening of the active sight made clave even better fit. And then it got even more complicated, because the e s s picked up inhibitor resistance mutations. We call them c m tsa, and we had those that inhibite resistant eso i r ts - they were also susceptible to s h v.