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Immunology for the Rheumatologist: The Devil Is in the Details

ACR Journals On Air

CHAPTER

Nucleases and Autoimmunity Unraveled

This chapter explores the impact of specific nucleases, particularly DNases, on autoimmune diseases like lupus, highlighting their genetic implications and deficiencies. It examines the relationship between preclinical autoimmunity, immune tolerance mechanisms, and factors influencing the progression to clinical manifestations.

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