The Impact of Psilocybin on Neural Connectivity and Emotional Rewiring

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How Psilocybin Can Rewire Our Brain, Its Therapeutic Benefits & Its Risks

Huberman Lab

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CHAPTER

The Impact of Psilocybin on Neural Connectivity and Emotional Rewiring

This chapter explores the crucial roles of electrolytes in cellular functions and cognitive performance during dehydration, particularly in neurons. It then examines the effects of psilocybin on brain connectivity and its potential therapeutic benefits, including rewiring emotional responses and enhancing creativity.

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In this episode, I discuss what psilocybin is (chemically) and how it works at the cellular and neural circuit level to trigger neuroplasticity, which is our brain’s ability to rewire itself in ways that lead to long-lasting shifts in our emotional, cognitive and behavioral patterns and abilities. I discuss the emerging clinical trial evidence for the use of psilocybin in the treatment of depression, addictions and other psychiatric challenges. I explain the typical duration and phases of a psilocybin journey, the different categories of dosages often used and I explain the importance of set, setting and support when using psychedelics. I explain which groups of people place themselves at great risk by taking psilocybin as well as groups that could benefit, and I highlight the rapidly changing legal and medical landscape around psilocybin. This episode is a thorough exploration of psilocybin from the scientific and clinical literature perspective and ought to be of interest to anyone curious about psilocybin, mental health, neuroplasticity and/or psychedelics more generally.

For the full show notes, visit hubermanlab.com.