Understanding Cachexia: Age, Gender, and Muscle Loss in Cancer Patients

Dr Glenn McConell chats with Associate Professor Lykke Sylow from The University of Copenhagen. She is a rising star in exercise metabolism and in particular the effect of exercise on cancer. This is the second podcast episode on exercise and cancer (See Professor Kathryn Schmitz episode #9).
Remarkably she said that if you are a non-smoker your biggest risk of getting cancer is inactivity. Not clear if this is independent of obesity etc. Can associated with a reduction of insulin sensitivity and also cachexia (with the loss of muscle mass is very important). The cancer itself may cause insulin resistance. Exercise can reduce the likelihood of getting cancer, improve the prognosis during cancer treatment and reduce the likely of getting cancer again. There is even evidence that exercise can improve the effectiveness of chemotherapy and reduce the extent of metastasis. Really remarkable stuff. A lot more research is needed to clarify these things. X: @lykkesylow
0:00. Introduction
2:40. Lykke is a rising star
3:59. Cancer and exercise overview
6:09. Wasting of muscle mass with cancer
7:00. Evidence that exercise reduces the risk of getting cancer
11:40. Inactivity / obesity and cancer
13:03. Glucose metabolism and cancer
15:20. Cancer cachexia
19:05. The cancer itself may cause insulin resistance
22:55. Cancer cachexia/ loss of muscle mass
29:30. When loss weight tend to lose muscle
30:30. Mechanisms of cancer cachexia
33:20. Pre cancer muscle mass/strength and survival
35:50. With cancer insulin resistance may come before cachexia
40:07. What do different cancers have different effects?
41:48. Exercise can improve tolerance to cancer treatment/fatigue
46:20. Does exercise reverse the insulin sensitivity with cancer
46:30. Exercise increases muscle glucose use during and after exercise
52:10. Exercise during chemotherapy treatment
54:55. What kind/type of exercise are we talking about?
1:01:20. Mechanisms/AMPK
1:03:25. Exercise reduces fatigue in cancer
1:04:13. Exercise may improve the effectiveness of chemotherapy
1:06:25. Exercise may reduce metastasis of cancer
1:08:30. Sex differences, cancer and exercise
1:12:20. Age, cancer and exercise
1:15:15. Availability of exercise in oncology departments
1:18:50. Diet vs exercise in cancer treatment
1:19:50. Strength vs endurance training with cancer
1:21:22. Takeaway messages
1:26:23. Outro
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
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Not medical advice