Understanding Smudge Cells and Lymphocytosis in Hematologic Diagnoses

This week, we start a new series, this time all about the ins-and-outs of chronic lymphocytic leukemia (CLL) / small lymphocytic lymphoma (SLL)! Whether practicing general internal medicine, hospital medicine, or hematology/oncology, you will likely come across a patient with CLL. First, we go through initial diagnosis of this disease!

Content:

- What is CLL? How is this different than SLL?

- What is the approach to diagnosis?

- Do you need a bone marrow biopsy? Imaging?

- How do we prognosticate patients?

- Are smudge cells always suggestive of CLL?

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