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Are you thinking about switching from tirzepatide to retatrutide? In this video, I’ll walk you through everything you need to know about making the transition—from the science and mechanisms, to real-world dosing strategies and the side effect differences I see in my community. If you’re looking for maximum fat loss and the most up-to-date peptide protocols, this video is for you.

Timestamps

0:00 – Introduction: Why the switch from tirzepatide to retatrutide is happening
0:45 – Clinical background: Compounding issues and the rising popularity of retatrutide
1:30 – My transition philosophy: Gradual tapering and best practices
2:04 – Mechanisms: How tirzepatide and retatrutide work in the body
3:10 – Tirzepatide: GIP and GLP-1 agonism explained
3:54 – Why tirzepatide has fewer side effects vs semaglutide
4:01 – Retatrutide: What does triple agonism mean?
4:42 – Metabolic advantages: Glucagon receptor activation, liver fat reduction, energy expenditure
5:45 – Head-to-head comparison: Why retatrutide is stronger for fat loss
6:51 – Dose escalation: How to titrate both drugs (side effects & protocol)
7:56 – Study outcomes: Average weight loss on both drugs
9:10 – A1C improvements: Comparing metabolic health markers
10:00 – Retatrutide’s liver benefits and impact on longevity
11:02 – What to expect when you switch: Side effects, hunger, and adaptation
12:02 – Appetite differences: Why tirzepatide suppresses appetite more at equal doses
13:30 – Side effect management: GI symptoms, heart rate, and tips
14:02 – My detailed titration schedule for switching safely
16:50 – Can you mix tirzepatide and retatrutide?
17:39 – Why minimum effective dosing matters and other fat loss pathways
18:01 – Final thoughts: Community support, feedback, and closing

In this video you’ll learn:
• The step-by-step protocol to taper down tirzepatide and introduce retatrutide safely
• Key differences in mechanisms (GIP/GLP-1 vs GIP/GLP-1/Glucagon)
• Real world data on weight loss, A1C, and fatty liver reduction
• My honest recommendations for side effect management
• How to listen to your body and titrate up for maximum effect
• Answers to common questions: can you combine both, and is the switch right for you?

The Dr. Berg Show LIVE - October 3, 2025

Dr. Berg’s Healthy Keto and Intermittent Fasting Podcast

Restoring low DHEA and its role

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