ApoB, Insulin Sensitivity, and Metabolic Health | 9min snip from The Human Upgrade with Dave Asprey

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Is Red Meat the Fountain of Youth? Paul Saladino : 1229

The Human Upgrade with Dave Asprey

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CHAPTER

ApoB, Insulin Sensitivity, and Metabolic Health

This chapter explores the intricate connection between ApoB levels and insulin sensitivity, highlighting the prevalence of metabolic dysfunction in the U.S. and questioning the efficacy of PCSK9 inhibitors. The discussion emphasizes the importance of a holistic approach to metabolic health, considering various biomarkers, dietary fats, and collagen's role in longevity.

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Does Calorie Restriction Even Work? What About the Carnivore Diet AND Fruit?

Today we are excited to have Paul Saladino join us for a masterclass on food and diets. Dr. Saladino dives into the evolution of keto and carnivore diets, cutting through trends to focus on lasting health impacts. Dr. Saladino, widely recognized as CarnivoreMD, shares how his own diet shifted to include fruit and honey alongside animal-based nutrition, and why metabolic flexibility—not rigid rules—leads to better outcomes. Together, he and Dave challenge assumptions about long-term ketosis, examine its potential downsides, and explore how to optimize diets for energy, gut health, and longevity.

They also tackle controversial topics like the risks of seed oils, the overhyped reputation of “health foods” like quinoa, and the critical roles insulin and nutrient density play in overall wellness. With insights on balancing mTOR, managing omega fats, and incorporating organ meats, this episode offers a nuanced perspective for anyone interested in biohacking, nutrition science, or simply eating smarter.

What you’ll learn:

• Why metabolic flexibility matters more than strict diet rules

• The science behind long-term ketosis and insulin’s broader role in health

• How common “health foods” could be doing more harm than good

• The importance of nutrient-dense animal-based foods for gut and immune health

• How to achieve optimal balance between fat types, mTOR, and longevity markers

Resources:

2025 Biohacking Conference – https://biohackingconference.com/2025

Shop Paul Saladino’s Products – https://heartandsoil.co

Follow Paul Saladino on Instagram – https://www.instagram.com/paulsaladinomd/

Paul Saladino’s Book: The Carnivore Code – https://www.amazon.com/Carnivore-Code-Unlocking-Returning-Ancestral/dp/035846997X

Lineage Provisions – 100% Grass-Fed Beef Tallow – https://lineageprovisions.com/products/100-grass-fed-beef-tallow