
Immune 52: B cell boot camp with Gabriel Victora
Immune
The Darwinian Process of Antibodies
AID is an enzyme used to introduce random mutations into the genome of a cell. Each one has a different mutation and you repeat this and, you know, rinse and repeat. Most cells are worse binders or just as bad as they were, but a few are actually pretty good. We can routinely in the lab get antibodies that are a thousand times better than what they started.
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