Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas cover image

16 | Coleen Murphy on Aging, Biology, and the Future

Sean Carroll's Mindscape: Science, Society, Philosophy, Culture, Arts, and Ideas

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How to Model Parkinson's Disease in Worms

We were trying to figure out, could we model parkinson's disease? And so if you just take it at its most a basic level, say it's an age related motor defect. Is there something that we could find in worms? And so that's why we started these assays where we would knock down the jeans from this list and then look at how that changed the worm's swimming behaviour. We really wanted to model what happens with age if you got rid of a gean,. So i'm doing that. The top 20 or so causes weird defect. They would curl up. And we'd never seen that before. So they curled up and uncurl, and they get stuck

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