On this inaugural episode of Out of Office, Lightspeed Partner Michael Mignano roams SoHo and Chinatown with filmmaker and YouTube icon Casey Neistat to explore how New York City became his lifelong muse—and how AI is about to reshape filmmaking. They explore Casey’s journey from camcorders and point-and-shoots to phones and drones, and debate why imperfect, human choices often beat pristine, over-engineered images, at least for now. Over rice and roast pork, they dig into authenticity vs. automation and what happens when algorithms can flood the zone with infinite, watchable content. They also look ahead to the “post-phone” era, when everyone has wearables, glasses, and single-purpose devices, and what that will mean for attention, creativity, and future generations.

Chapters:

0:00 Welcome to Out of Office

4:22 Tools, Authenticity & The Evolution of Filmmaking

11:53 AI as a Filmmaking Tool

14:11 The AI Tidal Wave & The Future of Content

20:01 Movies, Theaters and the Attention Economy

26:45 The Business of Video and AI Monetization

30:29 How AI Changes Creator Economics

35:16 What Happens to Big Creators Like MrBeast?

41:19 Peak Phone and the Next Wave of Devices43:12 Beme, Realness & The Lost Internet

47:23 From Startup to CNN & Lessons from the Acquisition

54:54 Can Media & News Survive AI?

59:05 Meta Glasses vs Vision Pro — The Next Interface

1:04:11 Parenting & Raising Kids in a Tech World

1:08:45 Casey’s Final Reflection: Purpose Over Success

ABOUT OUT OF OFFICE PODCAST:

Out of Office is a new podcast from Lightspeed for people who build, create, and think about what’s next. No studio. No Zoom. No filter. Host Michael Mignano, Partner at Lightspeed and Co-Founder of Anchor, steps out into the real world to talk with the most interesting minds in AI, tech, and media. We’re leaving the office behind, hanging out, asking real questions, and letting the conversations go wherever they lead.

Stay In Touch:

Website: http://www.lsvp.com

X: https://x.com/lightspeedvp

LinkedIn: https://www.linkedin.com/company/lightspeed-venture-partners/

Instagram: https://www.instagram.com/lightspeed/

Subscribe on your favorite podcast app: https://linktr.ee/ooolightspeed

Follow Michael:

X: https://x.com/mignano

TikTok: https://www.tiktok.com/@michael.mignano

LinkedIn: https://www.linkedin.com/in/mignano/

DISCLAIMER:

The content here does not constitute tax, legal, business or investment advice or an offer to provide such advice, should not be construed as advocating the purchase or sale of any security or investment or a recommendation of any company, and is not an offer, or solicitation of an offer, for the purchase or sale of any security or investment product. The views expressed by our guests do not necessarily represent the views of Lightspeed. For more details please see https://www.lsvp.com/legal.

Episode 229: Why Most Cybersecurity Advice Is Wrong

What the Hack?

Passphrases and password manager value

The AI-powered Podcast Player