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#133 – Manolis Kellis: Biology of Disease
Lex Fridman Podcast
Detecting Epigenomic Variation in Disease
The path between genetic variation and the expression of one gene goes through many enhancer regions. The hope is, or the most scientifically speaking, the most effective place where to detect the alteration that results in disease is earlier on in the pipeline as early as possible. So it's a trade-off. Each of these epigenomic alterations, for example, this enhancer control region is active, maybe 50% less than before.
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