Clovers for Sepsis-Induced Hypotension

Swami: The paper title was Early Restrictive or Liberal Fluid Management for sepsis-induced hypotension published in the New England Journal of Medicine 2023. And their secondary outcome of mortality was not statistically significantly different, although it did seem to favor that norepi group. But that kind of sets us up for why we need more studies in this area and brings us to the clover's trial. Swami: I wish they would have included patients who had evidence of fluid overload or patients who had signs of volume depletion. So you're talking about these extremes right now? We don't really know what is going on there. swami: It could be like our GI