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The Transcription-Translation Feedback Loop in Mammals and Fruit Flies
In this chapter, they discuss the transcription, translation feedback loop in mammals and fruit flies, where genes are transcribed and translated into proteins, which then regulate the transcription of other genes in a negative feedback loop with time delays. They explore the surprising discovery of a core clock circuit that exists in nearly every cell, including peripheral clocks, and speculate on why a clock is produced in every single cell.