The Transcription-Translation Feedback Loop in Mammals and Fruit Flies

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In this chapter, they discuss the transcription, translation feedback loop in mammals and fruit flies, where genes are transcribed and translated into proteins, which then regulate the transcription of other genes in a negative feedback loop with time delays. They explore the surprising discovery of a core clock circuit that exists in nearly every cell, including peripheral clocks, and speculate on why a clock is produced in every single cell.

Biological organisms are paradigmatic emergent systems. That atoms of which they are made mindlessly obey the local laws of physics; even cells and organs do their individual jobs without explicitly understanding the larger whole of which they are a part. And yet the system as a whole functions beautifully, with apparent purpose and function. How do the small parts come together to form the greater whole? I talk with biophysicist Rosemary Braun about what we're learning about collective behavior within organisms from the modern era of huge biological datasets, especially crucial aspects like timekeeping (with bonus implications for dealing with jet lag).

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Blog post with transcript: https://www.preposterousuniverse.com/podcast/2023/09/25/251-rosemary-braun-on-uncovering-patterns-in-biological-complexity/

Rosemary Braun received her Ph.D. in physics from the University of Illinois at Urbana-Champaign, and an M.P.H. in biostatistics from Johns Hopkins. She is currently an associate professor of molecular biosciences, applied math, and physics at Northwestern University and external faculty at the Santa Fe Institute.

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