Delving into the comparison of fatty acid profiles in cows, wild game, and grass-fed cows, this chapter discusses the evolution of human diet from hunting large fat-rich animals to leaner game. It also touches on the challenges of researching dietary options amidst agricultural interests and financial conflicts, addressing the controversies between feedlot and grass-finished animals. The chapter highlights the unique digestive system of humans, emphasizing our adaptability to different nutrients and the debate around processed foods like seed oils.

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