Personalized Guidance and Organ-Specific Clocks for Aging

Today: the clocks in your body.

We're talking again this week with Tony Wyss-Coray, the director of the Knight Initiative for Brain Resilience here at Wu Tsai Neuro. 

Last year, we spoke with Tony about the biological nature of the aging process. Scientists can now measure signs of aging in the blood, and can in some cases slow or reverse the aging process in the lab. We discussed how this biological age can be quite different from your chronological age, and why understanding why people age at different rates has become a hot topic for researchers who study aging. 

Since we last spoke, Professor Wyss-Coray and his lab have published some exciting new work that takes this idea from the level of the whole body down to the level of specific organs and tissues. We can now ask: are your brain, your heart, or your liver aging faster than the rest of you? The implications of this idea could be profound for both neuroscience and medicine more broadly.

Listen to the episode to learn more!

Further reading
Wyss-Coray lab
Phil and Penny Knight Initiative for Brain Resilience

Organ aging study in Nature:

• Organ aging signatures in the plasma proteome track health and disease (Nature, 2023)

Study coverage:

• Stanford Medicine-led study finds way to predict which of our organs will fail first (Stanford Medicine)
• Your Organs Might Be Aging at Different Rates (Scientific American)
• Tony Wyss-Coray: The Science of Aging (Ground Truths with Eric Topol)

Related reading:

• You can order a test to find out your biological age. Is it worth it? (NPR)
• What’s Your ‘Biological Age’? (New York Times)
  
  

Episode Credits

This episode was produced by Michael Osborne at 14th Street Studios, with production assistance by Morgan Honaker. Our logo is by Aimee Garza. The show is hosted by Nicholas Weiler at Stanford's Wu Tsai Neurosciences Institute and the Knight Initiative for Brain Resilience. 

Thanks for listening! If you're enjoying our show, please take a moment to give us a review on your podcast app of choice and share this episode with your friends. That's how we grow as a show and bring the stories of the frontiers of neurosc

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