Want to use peptides safely and effectively? In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith joins us to distill decades of clinical experience into a discussion on peptides for pain relief, fascia health, brain injury recovery, immune balance, and performance optimization. She shares real-world cases, practical protocols, and her philosophy on starting safely and effectively with these powerful tools.
In this episode of Peptides & Longevity, Dr. Kathleen O’Neil-Smith gives us a masterclass on the diverse applications of peptides in clinical practice. Drawing from her background in internal medicine, functional medicine, regenerative therapies, and athletic coaching, she explains how specific peptides can be matched to the type of injury or dysfunction—whether that’s joint degeneration, fascia restriction, immune imbalance, or neurotrauma. She emphasizes the importance of fascia as an interconnected signaling network and outlines how combining physical manipulation with targeted injections or intravenous therapy can produce rapid, lasting results.
Dr. O’Neil-Smith also details her personal experience using peptides to restore her son’s health after a severe traumatic brain injury, walking through the specific compounds, timing, and combinations she used for inflammation control, nerve regeneration, and whole-body recovery. The conversation expands into immune system assessment, gut-brain connections, mitochondrial health, performance optimization for elite athletes, and strategies for healthy aging. Throughout, she underscores that the key to success is starting somewhere with safe, foundational peptides and adapting as the patient’s needs evolve.
Dr. Kathleen O’Neil-Smith is a physician, lecturer, and researcher specializing in peptides, regenerative medicine, and functional health. A magna cum laude graduate of Boston University School of Medicine, she completed postgraduate training in pathology at Harvard/Mass General and internal medicine at Brigham and Women’s Hospital. With additional certifications in stem cell therapies, traumatic brain injury treatment, and exercise physiology, she has served as founder of the International Peptide Society and Clinical Peptide Society, and as a senior lecturer at leading medical conferences worldwide. Known for her innovative, compassionate approach, Dr. O’Neil Smith integrates advanced peptide protocols, medicinal signaling therapies, and performance strategies to help patients—from elite athletes to complex chronic cases—achieve optimal health and recovery.
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Integrative Peptides
Website: https://integrativepeptides.com/
Facebook: https://www.facebook.com/integrativepeptidesofficial/
Instagram: https://www.instagram.com/integrativepeptides/
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Holtorf Medical Group
Website: https://holtorfmed.com/
Facebook: https://www.facebook.com/holtorfmed/
Instagram: https://www.instagram.com/holtorfmedicalgroup/
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Kent Holtorf, MD
YouTube: https://www.youtube.com/channel/UC0S6Kaa1V9-dfo2sPyZPT6A
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Produced by DrTalks https://drtalks.com/podcast-service/
