Intro

Get ready to upgrade your cardiovascular health in a way you’ve never heard of before. Dave Asprey sits down with Dr. Michael Twyman, a pioneering biohacking cardiologist who blends cutting-edge functional medicine with conventional wisdom to help you avoid heart attacks and strokes. If you think cardiovascular disease is inevitable, think again. Dr. Twyman reveals the hidden mechanisms behind heart disease, starting with the misunderstood role of plaque in your arteries and the essential yet underappreciated glycocalyx—a slippery gel-like coating that could be the key to preventing arterial damage. 

From there, it’s all about prevention, prevention, prevention. Want to know how simple lifestyle tweaks can significantly reduce your risk of cardiovascular events? We’ve got the biohacks—grounding, sunlight exposure, cold plunges, and more—laid out for you in a step-by-step, easy-to-apply format. Dr. Twyman breaks down the crucial role of circadian biology and how aligning your body clock with natural light cycles can help protect your heart. Plus, learn why grounding might just be the ultimate, free anti-inflammatory tool you’ve been missing. 

This episode isn’t just about tips and tricks—it’s a complete roadmap to understanding and optimizing your heart health. Dave and Dr. Twyman get into the nitty-gritty of lab tests you should be asking for, why exercise is only part of the solution, and how the current medical insurance model fails to protect your cardiovascular future. Don’t miss out on these life-saving insights that are rooted in both ancient wisdom and modern science. 

Sponsors:  

• Viome | Go to https://viome.com/dave to save $110 on the Full Body Intelligence Test. 
• fatty15 | Go to https://fatty15.com/dave and save an extra $15 when you subscribe with code DAVE. 

Resources: 

• Calroy Health Sciences: https://calroy.com/ 
• Dr. Michael Twyman’s Website: https://www.apollocardiology.com/ 
• Follow Dr. Michael Twyman on Instagram: https://www.instagram.com/drtwyman 
• Dave’s Linktree: linktr.ee/daveasprey 
• Dave Asprey’s Book ‘Smarter Not Harder’: daveasprey.com/books 
• Want to join The Human Upgrade Podcast Live? Join Our Upgrade Collective: https://www.ourupgradecollective.com/    
• Danger Coffee by Dave Asprey: https://www.instagram.com/dangercoffeeofficial/  
• Supplements by Dave Asprey: https://shopsuppgradelabs.com/  
• Own an Upgrade Labs: https://ownanupgradelabs.com/ 

Timestamps and Highlights: 

• 00:00 — Introduction to Cardiovascular Health 

• 01:22 — Meet Dr. Michael Twyman 

• 05:57 — Understanding Heart Attacks 

• 08:09 — The Role of Glycocalyx in Cardiovascular Health 

• 15:17 — Lifestyle Changes for Cardiovascular Health 

• 24:32 — Exercise and Cardiovascular Health 

• 27:58 — Effective VO2 Max Strategies 

• 28:12 — Patient Exercise Goals and Time Management 

• 29:12 — Thyroid and Cardiovascular Health 

• 32:49 — Circadian Biology and Heart Disease 

• 33:57 — Sunlight, Grounding, and Seasonal Health 

• 38:49 — The Role of Statins in Cardiovascular Health 

• 43:16 — Key Labs for Cardiovascular Risk Assessment 

• 50:33 — Insurance and Preventative Health 

• 54:35 — Conclusion and Final Thoughts 

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