The Role of Melatonin in Heart Failure

Melatonin gets into the system very, very quickly. The bioavailability of melatonin that is swallowed is less thanmelatonin where you take it under the tongue or if you take it intravenously because you avoid that first pass effect. What about rectally? Segan: There's relatively, there was a gentleman, I forgot his name, five years ago, who contacted me about rectal suppositories. So far as I know, the only size available in rectal suppository, but you may know otherwise, are 250 milligrams.