The chapter delves into the relationship between LDL cholesterol levels and plaque burden, emphasizing the importance of addressing metabolic issues through diet and lifestyle changes. The discussion involves the involvement of ApoB-containing particles in atherosclerotic plaque formation and debates the decision to lower ApoB levels without clear downsides. The chapter also explores the complexities of lowering LDL levels, highlighting the need to consider individual metabolic health in the risk-benefit calculation.

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