#63 - Adipose tissue adaptations to exercise and exercise and antipsychotics with Dr David Wright
Inside Exercise
Introduction
Professor David Wright discusses the regulation of mitochondrial content in muscle and fat due to exercise, as well as the ability of exercise to prevent increased glucose levels caused by antipsychotics.
Dr Glenn McConell chats with Professor David Wright from the University of British Columbia, Canada. He has undertaken a lot of important work on the effect of exercise on muscle glucose uptake and mitochondria and then has branched out to examine the effect of exercise training on mitochondria in adipose tissue (fat). We discussed his work around that and then talked about an interesting new focus of his work around the metabolic effects of antipsychotics. He is finding that exercise can prevent the acute blood glucose raising effects of antipsychotics. A very interesting chat.
0:00. Introduction and how David got into research
6:10. His transition from muscle to fat research
10:05. Exercise activates AMPK in muscle and fat
10:57. Adipose tissue breakdown during exercise
13:58. Adrenaline/epinephrine
15:28. Exercise training effects on fat mitochondria
21:00. Why so much fat turnover during exercise
24:00. Fat use during ex in lean vs obese
26:25. Adrenaline regulation of fat adaptations to ex training
29:50. AMPK regulation of fat
32:05. Cross talk between organs during exercise
34:55. White, beige, brown adipose tissue
39:00. Human vs rodents brown adipose tissue
44:25. Adipokines and exercise training
48:40. Ectopic fat
49:40. Antipsychotics, obesity and diabetes
51:15. Each dose of an antipsychotic increases blood glucose
53:00. Exercise prevents these glucose effects of antipsychotics
59:00. GLP-1, glucagon and antipsychotics
1:03:20. Poor exercise adherence, do fasting instead?
1:05:15. Ketogenic diets and antipsychotics
1:08:50. Ketogenic diets and mental health
1:11:03. Clinicians awareness etc.
1:12:45. Sex and age differences
1:15:00. Acute vs chronic effects
1:15:40. Takeaway messages
1:19:27. Outro (9 seconds)
Inside Exercise brings to you the who's who of research in exercise metabolism, exercise physiology and exercise’s effects on health. With scientific rigor, these researchers discuss popular exercise topics while providing practical strategies for all.
The interviewer, Emeritus Professor Glenn McConell, has an international research profile following 30 years of Exercise Metabolism research experience while at The University of Melbourne, Ball State University, Monash University, the University of Copenhagen and Victoria University.
He has published over 120 peer reviewed journal articles and recently edited an Exercise Metabolism eBook written by world experts on 17 different topics (https://link.springer.com/book/10.1007/978-3-030-94305-9).
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