The endothelium is the inner lining of your arteries it's one cell thick that coats the entirety of the 60,000 miles of blood vessels. When nitric oxide becomes low things tend to start sticking to the artery so for younger people they may not remember what Teflon actually is but when you have high levels of nitric oxide the lipoproteins the white blood cells the platelets just zoom on through the lumen kind of like a maglev train and just slide right through. The body tries to scar down these soft plaques by eating them which will calcify as a stabilizing factor later in life.

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