Exploring Longevity and the Nine Hallmarks of Aging with Chris Mirabile

If there is one thing that humanity has been striving for since its inception, is the pursuit of longevity. Today I’m with Chris Mirabile, Founder & CEO of NOVOS Labs who brings us one step closer to cracking the code of aging and longevity and offers fascinating insight into the intersection of health, performance, and longevity. We discuss how short-term health strategies may not always contribute positively to longevity, and the nine hallmarks of aging that NOVOS Labs aims to address. These include loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. 

Chris’s interest in health began when he was 12 and evolved into a passion after he was cured of a brain tumor when he was 16. Chris has researched and integrated longevity practices and interventions into his life for more than ten years, has achieved a biological age 13.6 years younger than his chronological age, and according to epigenetic tests like DunedInPACE, is aging 31% slower biologically than chronologically. As we dive deeper into the realm of aging and anti-aging strategies, we bring ourselves one step closer to a future where longevity is not just a dream, but a reality.

Chris Mirabile graduated from NYU Stern School of Business and later won their business plan competition with his startup company, Hotlist, a location-based social network that scaled to 220 million people’s social plans. Chris has launched multiple successful technology ventures and has advised biotech startups and NYU Langone Hospital. 

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What we discuss:

(0:03:00) - The Short-Term Health vs. Longevity Dilemma

(0:10:34) - Balancing Strategies for Longevity

(0:19:29) - Aging and Anti-Aging Formulations

(0:28:32) - Autophagy and Microbiome in Aging

(0:39:26) - Understanding Senescent Cells-Safest Approach

(0:53:55) - Comparing Different Aging Clocks

Key takeaways:

• Aging and longevity are complex processes with numerous factors at play, such as loss of proteostasis, DNA damage, attrition of telomeres, mitochondrial dysfunction, cellular senescence, altered cellular communication, dysregulated nutrient sensing, epigenetic alterations, and telomere shortening. 
• Senescent cells, while often perceived negatively due to their contribution to aging, can also play beneficial roles in certain contexts such as wound healing and limiting fibrosis. However, current senolytics can pose risks due to potential toxicity and lack of precision in targeting the right cells.
• While strategies such as severe caloric restriction or prolonged fasting can contribute to longevity, they may also have detrimental effects on short-term health and performance. It's crucial to strike a balance and consider the long-term implications of these health strategies. The ideal time to start implementing longevity strategies, like Novos, is around late 20s to early 30s.