Using Crioet to Identify a Protein in a Cell

Criopib milling allows researchers to slice cells thinly before placing them under an elec microscope. Baumeister and his colleagues used this mash up of methods to visualize how molecules were arranged in the vicinity of the nucleus in a human cell. Their work revealed how nanometer thin filaments provided structural support to the nucleus, making it one of the stiffest organels in animal cells.