Synergistic Nephrotoxicity in Drugs

Drugs associated to kidney injury and particularly drugs that, you know, may be a result in synergistic nephrotoxicity. What do you think are some drug drug interactions that have gotten a bad rap over the years that you feel need to be explored a little bit more? Yeah, well, I can talk about one that we've done some work in. So, NSAIDs cause vasoconstriction of the aferic arteriol that's the blood vessel going into the glomerulus. And so, if, so that also lowers intraglimarular pressure, which lowers GFR. Both drugs can cause a lower GFR. When given in combination, it's thought