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EP. 58: YOUR BRAIN ON DEPRESSION: DR. JOHN KRYSTAL ON ANTIDEPRESSANTS, PSYCHEDELICS, AND KETAMINE THERAPY

Bounce! Conversations with Larry Weeks

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The Effects of Ketamine on Depression

Ketamine may raise brain-derived neurotrophic, in other words, nerve growth factor, BDNF. By creating a pulse of glutamate release, it triggers a signal in the brain that the pathways are being meaningfully activated. And by stimulating a particular type of glutamate receptor called the AMPA glutamate receptor, you might say it steps on the gas and helps to raise that BDNF level.

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