In a trending paper published by Oncotarget on March 2, 2021, titled, “Quantitative proteome profiling stratifies fibroepithelial lesions of the breast,” researchers from India conducted a study to better characterize phyllodes tumors and other breast fibroepithelial lesions in order to improve diagnosis and treatment for patients.
To begin identifying the differentially expressed genes and proteins among FAD and PTs in benign, borderline, and malignant states, the researchers conducted quantitative global proteomics on Formalin-Fixed Paraffin-Embedded (FFPE) tissue sections. They conducted a principal component analysis of the protein expression matrix to identify the overlapping proteomic profiles among FELs.
“Interestingly, we observed FADs and benign PTs clustered together compared to borderline and malignant ones, albeit with overlapping protein expression profiles.”
Read the full study: doi.org/10.18632/oncotarget.27889
Oncotarget Volume 12, Issue 6: oncotarget.com/archive/v12/i6/
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