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Episode 178: Karl Herrup discusses the shortcomings of Alzheimer’s research

STEM-Talk

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Rethinking Alzheimer's Research

This chapter explores the historical evolution and controversial aspects of Alzheimer's disease research, particularly focusing on the amyloid plaques and tau tangles in relation to the disease. It critiques the reliance on these deposits as diagnostic criteria, highlighting discrepancies between biological evidence and clinical symptoms. The discussion raises pivotal questions about the efficacy of animal models and recent anti-amyloid therapies, emphasizing a disconnect between amyloid accumulation and cognitive impairment.

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