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Noninferiority Trials: Is a New Treatment Almost as Effective as Another? with Dr Amy Kaji

JAMAevidence JAMA Guide to Statistics and Methods

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Selecting the Minimally Important Clinical Difference and Sample Size for Trials

This chapter explores the importance of determining the MCID in trial design, as it significantly impacts the publishability of trials in JAMA. The speaker emphasizes the need to establish sample size based on the MCID for different types of trials.

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