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Children with Down's syndrome are more likely to get leukaemia: stem-cells hint at why

Nature Podcast

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Leukemia Risk in Down Syndrome: Unraveling Fetal Origins

This chapter explores the significantly increased risk of leukemia in children with Down syndrome, investigating the role of hematopoietic stem cells during fetal development. Researchers analyze how an extra chromosome 21 affects chromatin structure and gene expression, affecting blood cell types and raising leukemia susceptibility. The insights derived from single-cell sequencing and chromosomal studies aim to enhance understanding and improve treatment outcomes for those affected.

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