Insulin Resistance in Diabetes

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Saturated fats can increase liver fat and cause mild insulin resistance. Evidence that it's linked with oxidative stress to the mitochondria in both situations. So there may be like a common pathway to the very end, you know, so where they separate.

Episode #233. Dive deeper into how saturated fats and sugar affect metabolism and the liver in this conversation with Dr Richard Johnson. The Proof community had many questions after Dr Johnson’s appearance on Episode #215, and we return today to answer them: What does human outcome data say? What are the risks of the keto diet and high blood sugar? Do our opinions align?

We answer these questions and more, addressing:

Intro (0:00)
Dr. Johnson’s Thesis on Fructose (3:27)
Gaps in Current Studies (11:28)
Saturated Fat Versus Sugar (20:20)
Long-term risk of Keto Diet (33:09)
Fructose Effect on Saturated Fat (36:28)
Survival Mechanisms (40:40)
Type of Fat (46:37)
Metabolic Health & Fructose (53:00)
Role of the Liver (1:02:20)
Problem with High Blood Sugar (1:09:15)
Triglycerides & Uric Acid (1:17:22)
When Fatty Liver Happens (1:27:52)
Ceramides (1:31:45)
Outro (1:33:30)

To connect with Dr Richard Johnson, you can find him on Instagram and Twitter, or learn more on his website. For a more comprehensive picture of Dr Johnson’s stance, make sure to check out his book, Nature Wants Us To Be Fat.

Discover additional resources, supporting studies, and more insights in the full show notes.

Enjoy, friends.

Simon

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Simon Hill, Msc, Bsc (Hons)

Creator of TheProof.com and host of The Proof with Simon Hill

Author of The Proof is in the Plants

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