Understanding Acute Promyelocytic Leukemia

This chapter focuses on the clinical features and laboratory findings of acute promyelocytic leukemia (APL), emphasizing the unique morphological traits of APL blasts and the essential role of flow cytometry for accurate diagnosis. It explores the genetic foundations of APL, including the PML-RARA fusion gene, and highlights the critical importance of prompt treatment with all-trans retinoic acid (ATRA). Furthermore, the chapter addresses management strategies for complications like disseminated intravascular coagulation (DIC) and discusses advanced diagnostic techniques for confirming the presence of APL.

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