There's many ways to skin a cat when it comes to what can cause insulin resistance. The two most evidence based substances that we know for sure causes insulin resistance from human clinical trials would be refined carbohydrates and refined sugars 100%. Over consuming megasucceed oils, particularly if they are not like cold pressed,. Particularly at a high dose, which most people are consuming - the average American gets about 20% of their calories from soybean oil alone. So there's hormone, there's a lot of hormone things to that can induce insulin resistance.

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