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TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease

This Week in Neuroscience

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Gut Impacts on Parkinson's Cognitive Decline

This chapter explores how preformed fibrils in the gut affect cognitive functions related to Parkinson's disease, using mouse models to demonstrate impacts on motor skills and memory. It highlights the interactions between gut health, alpha-synuclein misfolding, and neurodegenerative processes, suggesting a significant relationship between the enteric nervous system and cognitive deficits associated with Parkinson's.

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