TWiN 30: Gut to brain spread of alpha-synuclein in Parkinson's disease

The hosts kick off with funny weather stories before diving into the serious realm of Parkinson's disease. They discuss groundbreaking research showing how gut-injected alpha-synuclein can spread to the brain, triggering the disease. The multifaceted nature of Parkinson's, including motor and cognitive impacts, takes center stage. Exciting insights reveal the gut as a potential origin for disease pathology. The conversation also unpacks the role of misfolded proteins in neurodegeneration, emphasizing the connection between gut health and cognitive decline.