Does Chronic Inflammation Delivered by Interferon Alpha Change Serotonin Metabolism?

In chronic inflammation, tryptophan is shunted away from serotonin into something else called kinaerine. The more that enzyme gets kicked up, the more depressed people get under chronic inflammation. You can look at the ratio of kinarenic toTryptophan in blood and spinal fluid. And that tells you how active that enzyme is. We got spinal fluid and showed that indeed, and this is really interesting, that the inner fluid definitely jacks up kinarenin.

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