There's a number of neurotransmitters that release from your brain and actually walk the way down into the gut microbiome, things like serotonin and dopamine. Then there are neurotransmitters and neuropeptides and things like leptin and serotonin, they're created in the gut and then have an impact on the brain. Then we have the immune signaling,. I talked about that earlier on, the immune response. There are certain signals that come out of that that have an impacton the brain. And then you have integrity of the barrier that I mentioned a little bit earlier on. These short chain fatty acids, things like butyrate and acetate that are actually created by certain microbiome species digesting