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24min chapter
Immune 78: Tolerance and tolerating many vaccines
Immune
Modifying Antigens to Suppress Established Immune Responses
Exploring the challenges of immune tolerance and intervening in ongoing autoimmune responses through modifying antigens to target antigen-presenting cells for a toleragenic response. The chapter discusses inducing antigen-specific tolerance and the mechanisms behind generating a toleragenic response, emphasizing the importance of T cell responses and cytokine production in inducing tolerance. Experimental studies demonstrating reductions in T cell numbers and activity with the use of glycosylated antigens are discussed, highlighting the potential impact on autoimmune conditions like multiple sclerosis.
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