Immune 78: Tolerance and tolerating many vaccines
Immune
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Modifying Antigens to Suppress Established Immune Responses
Exploring the challenges of immune tolerance and intervening in ongoing autoimmune responses through modifying antigens to target antigen-presenting cells for a toleragenic response. The chapter discusses inducing antigen-specific tolerance and the mechanisms behind generating a toleragenic response, emphasizing the importance of T cell responses and cytokine production in inducing tolerance. Experimental studies demonstrating reductions in T cell numbers and activity with the use of glycosylated antigens are discussed, highlighting the potential impact on autoimmune conditions like multiple sclerosis.
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