Moderate Calorie Restriction Slows Aging

This episode covers: 

• Nano CBD Pain Relief Without Cognitive Side Effects 

A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support. 

Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm    

• Moderate Calorie Restriction Slows Biological Aging 

A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting. 

Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults   

• FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s 

The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair. 

Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/   

• Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules 

Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.” 

Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged) 

• Klotho: The Longevity Protein Nears Clinical Reality 

The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols. 

Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged) 

All source links provided for easy reference to the original reporting and research above. 

This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health. 

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living. 

New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. 

Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates  

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• 40 Years of Zen: https://40yearsofzen.com 

Timestamps: 

0:00 — Intro 

0:19 — Story 1: Nano CBD for Pain Relief 

1:53 — Story 2: Caloric Restriction and Aging 

3:20 — Story 3: AI Robotic Surgery for Alzheimer’s 

4:50 — Story 4: Microbiome Reprogramming 

6:05 — Substack Announcement 

7:04 — Story 5: Klotho Longevity Protein 

8:39 — Weekly Homework 

9:31 — Outro 

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