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#60 - Skeletal muscle aging and mitochondria: thinking beyond the powerhouse with Dr Russell Hepple

Inside Exercise

CHAPTER

Mitochondrial Alterations and Permeability Transition in Cancer

The chapter explores the role of caspase 3 in denervation and neuromuscular junction alterations, as well as the connection between permeability transition and caspase 3. It discusses the impact of cancer on mitochondrial function and skeletal muscle, including experiments using pancreatic cancer cells and chemotherapy agents. The chapter also emphasizes the potential benefits of exercise in protecting muscle from damage and highlights the importance of considering the various functions of mitochondria in skeletal muscle research.

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