Pyruvate acts as the emergency oxidizing agents for NADH through an enzyme called lactate dehydrogenase. All people with diabetes, insulin resistance and cardiovascular disease have higher than normal levels of lactic acid in their blood. So anything that we can do to either limit the supply of fat or increase the relative abundance of glucose relative to the fat should have therapeutic effects.
This week, Paul has Georgi Dinkov back on the podcast for the third time to cover a plethora of topics: the benefits versus risks of carbohydrates, polyunsaturated fatty acids in cell membranes, the root causes of diabetes and cancer, and so much more.
00:08:45 Raising children in the modern world
00:10:10 Can we extend our lifespan through fasting and Metformin?
00:18:40 High intensity interval training and other kinds of exercise
00:24:10 Protein, glycine, and preventing sarcopenia
00:30:30 Inflammation and endotoxins
00:39:10 Stop fearing blood glucose levels
00:43:10 Downsides of fasting and how to obtain autophagy
01:01:05 Thoughts on metformin
01:10:03 What causes diabetes?
01:28:50 Polyunsaturated fats behave differently than saturated fats