What Do Isocaloric Trials Say About Sugar and Weight?

Is sugar really to blame for the obesity epidemic? In this episode, I break down one of the most common nutrition myths. Using evidence from epidemiology, randomized controlled trials, and meta-analyses, Layne explains why sugar and high fructose corn syrup aren’t the independent culprits they’re often made out to be. Instead, he reveals what the research actually says about calories, metabolism, and how oversimplified narratives mislead the public. If you’ve ever been told “sugar is poison,” this episode will challenge your perspective with science, not fear.

SPONSORS

• REPS Research Review: https://biolayne.com/reps

• Carbon Diet Coach – Achieve your goals with Carbon’s adaptive macro coaching app: https://joincarbon.com/podcast

LAYNE'S COMPANIES

Carbon Diet Coach: https://joincarbon.com/podcast

Outwork Nutrition: https://outworknutrition.com

REPS Research Review: https://biolayne.com/reps

Workout Builder: https://biolayne.com/workout-builder

Team Biolayne: https://biolayne.com/online-coaching

Physique Coaching Academy: https://physiquecoachingacademy.com

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TIMESTAMPS

0:00:00 - Intro

0:02:49 - Research Funding and Bias

0:14:52 - Previous Beliefs on Sugar

0:15:31 - Types of Sugar

0:17:42 - Previous Beliefs on HFCS

0:19:37 - Leptin

0:23:56 - Gary Taubes

0:24:33 - REPS

0:25:22 - Carbohydrate Insulin Model of Obesity

0:27:42 - The Case for Sugar Causing Obesity

0:30:08 - The Moment I Started to Change My Mind

0:32:29 - Ice Cream

0:34:18 - Researching Sugar

0:39:15 - Mechanisms vs Outcomes

0:41:10 - Classic Study

0:42:28 - Mark Haub Twinkie Diet

0:45:46 - Carbon Diet Coach

0:46:46 - Metabolic Health

0:48:03 - Glycemic Index

0:49:51 - Sugar Intake vs Calorie Intake

0:52:30 - Sugar Addiction

0:54:21 - Let's Be Clear

0:56:36 - Data Over Feelings

SHOW NOTES

https://biolayne.com/podcasts/dr-layne-norton-podcast/did-sugar-cause-the-obesity-epidemic-episode-12