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Adjustment for Baseline Characteristics in Randomized Clinical Trials

JAMAevidence JAMA Guide to Statistics and Methods

CHAPTER

Adjustment for Baseline Characteristics and Interpretation of Trial Results

This chapter explores the impact of adjusting baseline characteristics on treatment effect estimates, focusing on a trial that used a Cox Proportional Hazards model. The authors discuss the numerical results, including a Hassett ratio of 0.97 with a narrow confidence interval of 0.90 to 1.05, and highlight the importance of this adjustment for accurate interpretation of the trial's findings.

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