How do you know if someone is susceptible to Alzheimer's if they don't yet have symptoms? I think the two most important way is our family history. So that's a big predictor. And then the second genetics. The APOE gene used to only exist in an isoform called E4. That was the one that we historically had for thousands of years. But it turns out to not be as good a gene to have when you're given that you don't need help with your genes to fight infectious diseases anymore.

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