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EP. 58: YOUR BRAIN ON DEPRESSION: DR. JOHN KRYSTAL ON ANTIDEPRESSANTS, PSYCHEDELICS, AND KETAMINE THERAPY

Bounce! Conversations with Larry Weeks

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The Antidepressant Response to Ketamine

The antidepressant response to ketamine depends on maintaining these newly formed synaptic connections. And so in animal studies, when they prevented those newly created neurotransmitters from lasting, the antidepressant response was really very brief. But when they allowed them to go the full length and they got the much longer response. In humans that may actually even turn into a new treatment where we gave a drug that may have protected this newly createdaptic from being broken down.

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