Exploring Epitope Recognition and Immune Responses in COVID-19

This chapter delves into the recognition of epitopes in the upper respiratory tract and oral cavity, discussing the average number of epitopes recognized, clinical outcomes of COVID-19, and heterogeneity in T cell responses. The correlation between T cell, B cell, and antibody data in relation to disease severity, impact of antigen persistence on memory, and potential pre-existing immune memory are also explored. The challenges in defining immunity to common cold coronaviruses and the search for suitable animal models for cross-protection testing are highlighted.